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Furthermore, the specific roles of the alternative pathway in high-inflammatory contexts, such as chronic infections where TNF receptor superfamily members (e.g., OX40, GITR) are actively engaged, still require further elucidation (138, 139)

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Some evidence suggests nasal delivery may be more effective than sublingual for certain peptides due to the different characteristics of nasal epithelial tissue

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In particular, Sox9 has been shown to play a major role in the commitment of progenitor cells to the chondrogenic fate